”Most children with a fever have a self-resolving viral infection like a flu, but a small number have life-threatening bacterial infections such as meningococcal disease,” Dr Coin said.
“Our method will prevent the unnecessary prescription of antibiotics to children with viral infections, and ensure dangerous bacterial infections don’t go undetected.”
Dr Coin said previous studies had suggested that specific infections could be identified by the pattern of genes activated by the fever.
“We analysed the gene patterns in the blood of children presenting with a fever at some hospitals in the United Kingdom, Spain, the Netherlands and the United States between 2009 and 2013, and discovered two genes that can distinguish bacterial infection from other causes of fever,” he said.
Dr Coin said multidrug-resistant bacteria, or superbugs, were serious cause for concern.
“Unless we tackle this problem, by 2050 superbugs could be claiming the lives of 10 million people each year,” he said.
“Over-prescription of antibiotics is significantly contributing to the rise of superbugs, so this discovery is a major breakthrough in this serious global challenge.
“The biomarker we discovered has the potential to diagnose other childhood diseases, including lupus and juvenile arthritis.”
The research team will seek to translate the discovery into clinical tests suitable for use in hospitals.
“We need to conduct more research, but we are quite confident we will be able to harness existing DNA sequencing technology to develop a revolutionary low-cost and rapid way to analyse and diagnose infections in children,” Dr Coin said.