Researcher biography

Carol Wicking is in the Division of Genomics of Development and Disease at the Institute for Molecular Bioscience, The University of Queensland, and is the Director of the IMB Centre for Rare Disease Research. Her research expertise spans a number of disciplines including human genetics, and cell and developmental biology. Her current research aims to understand the molecular and mechanistic basis of rare diseases, with a particular focus on a class of rare genetic disorders known as ciliopathies


Carol Wicking obtained her PhD from London University in 1991, for research on the molecular genetics of cystic fibrosis. She joined UQ as a postdoctoral fellow in 1992 under the supervision of Brandon Wainwright, and in this position was involved in the successful isolation of the gene for a cancer predisposition syndrome known as Gorlin's syndrome. From 1998 she established her own independent research group at UQ, initially exploring the role of hedgehog signalling in organogenesis, particularly in patterning of the limb, craniofacial complex and skeleton. Her current research focus is on a class of rare congenital disorders known as ciliopathies. Her group has recently been involved in the identification and characterisation of a number of novel genes responsible for various ciliopathies.

Key Discoveries

  • Identification of Patched as the gene for Gorlin's syndrome and for the sporadic form of the common skin cancer basal cell carcinoma (Published in Cell 1996)
  • The identification and characterisation of 3 novel genes for the skeletal ciliopathies Jeune and short rib polydactyly syndromes (Published in American Journal of Human Genetics x2, 2013; Nature Communications 2015)